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Measles & Rubella Dynamics

Working towards control, elimination, and eradication of one the world's most infectious diseases.

The Measles & Rubella Dynamics project is a collection of work focused on improving and achieving measles and rubella control, elimination, and eradication. To achieve this, we are conducting studies and developing methods to better estimate true vaccination coverage and immunity, estimate risk of outbreaks, identify whether vaccination goals are being met, and inform vaccination strategies and policy.

We are engaged with the WHO Measles Special Advisory Group of Experts (SAGE) to define and respond to existing challenges in reaching the goals of the Measles & Rubella Initiative (http://measlesrubellainitiative.org/). Through this collaboration, and in collaboration with our partners at the University of Princeton, Pennsylvannia State University, and The U.S. Centers for Disease Control, we are working to understand and develop tools to combat the challenges to effective immunization and elimination of these diseases.

Principal Investigator

Justin Lessler Associate Professor

Updates #measles

6 months 1 week ago

Congratulations to @Shaun_Truelove on his excellent dissertation defense. A well deserved new PhD from @JohnsHopkinsEPI. #measles
9 months 2 weeks ago

RT @NatureComms: The geography of #measles vaccination in the African Great Lakes region https://t.co/1eFmeUmkY4 by @JustinLessler… https://t.co/zZlzr6mlSY
1 year 7 months ago

Years in the making, @JustinLessler and @CJEMetcalf's work on triggered vax campaigns out in @PLOSMedicine https://t.co/RRdIaggMci #measles

Funders

The Bill and Melinda Gates Foundation

Collaborators

World Health Organization

US Centers for Disease Control and Prevention

Princeton University

The Pennsylvania State University

Publications

Demographics, epidemiology and the impact of vaccination campaigns in a measles-free world–Can elimination be maintained?

Prada JM, Metcalf CJE, Takahashi S, Lessler J, Tatem AJ, Ferrari M.

Vaccine, 2017: 35(11): 1488-93, 10.1016/j.vaccine.2017.02.008

The geography of measles vaccination in the African Great Lakes region.

Takahashi S, Metcalf CJE, Ferrari MJ, Tatem AJ, Lessler J.

Nat Commun, 2017: 8: 15585, 10.1038/ncomms15585.

Use of serological surveys to generate key insights into the changing global landscape of infectious disease.

Metcalf CJ, Farrar J, Cutts FT, Basta NE, Graham AL, Lessler J, Ferguson NM, Burke DS, Grenfell BT.

Lancet, 2016: 10.1016/S0140-6736(16)30164-7

Impact on Epidemic Measles of Vaccination Campaigns Triggered by Disease Outbreaks or Serosurveys: A Modeling Study.

Lessler J, Metcalf CJE, Cutts FT, Grenfell BT.

PLoS Med, 2016: 13(10): e1002144: 10.1371/journal.pmed.1002144

Reduced vaccination and the risk of measles and other childhood infections post-Ebola.

Takahashi S, Metcalf CJ, Ferrari MJ, Moss WJ, Truelove SA, Tatem AJ, Grenfell BT, Lessler J.

Science, 2015: 347: 1240-2, 10.1126/science.aaa3438

Quantifying seasonal population fluxes driving rubella transmission dynamics using mobile phone data.

Wesolowski A, Metcalf CJE, Eagle N, Kombich J, Grenfell BT, Bjornstad ON, Lessler J, Tatem AJ, Buckee CO.

Proc Natl Acad Sci U S A, 2015: 112(35): 11114–1111, 10.1073/pnas.1423542112

Mitigating measles outbreaks in West Africa post-Ebola.

Truelove SA, Moss WJ, Lessler J.

Expert Rev Anti Infect Ther, 2015: 13: 1299-301, 10.1586/14787210.2015.1085305

Measles elimination: progress, challenges and implications for rubella control.

Cutts FT, Lessler J, Metcalf CJ.

Expert Rev Vaccines, 2013: 12: 917-32, 10.1586/14760584.2013.814847

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