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HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

2 months 2 weeks ago

RT @JustinLessler: Preprint with our look at the literature on #HIV incidencenin sub-Saharan Africa with @KateGrabowski and… https://t.co/6Hj4ac7HU3
3 years 3 months ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
3 years 10 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
4 years 2 months ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
4 years 3 months ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
4 years 7 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
4 years 7 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

1 Oct 2010

Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002.

Conroy SA, Laeyendecker O, Redd AD, Collinson-Streng A, Kong X, Makumbi F, Lutalo T, Sewankambo N, Kiwanuka N, Gray RH, Wawer MJ, Serwadda D, Quinn TC; Rakai Health Sciences Program.

AIDS Res Hum Retroviruses, 2010: (10): 1087-91, 10.1089/aid.2010.0054

6 May 2010

HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.

Hollingsworth TD, Laeyendecker O, Shirreff G, Donnelly CA, Serwadda D, Wawer MJ, Kiwanuka N, Nalugoda F, Collinson-Streng A, Ssempijja V, Hanage WP, Quinn TC, Gray RH, Fraser C

PLoS Pathog, 2010: 6(5): e1000876, 10.1371/journal.ppat.1000876

1 Jun 2010

HIV-1 viral subtype differences in the rate of CD4+ T-cell decline among HIV seroincident antiretroviral naive persons in Rakai district, Uganda.

Kiwanuka N, Robb M, Laeyendecker O, Kigozi G, Wabwire-Mangen F, Makumbi FE, Nalugoda F, Kagaayi J, Eller M, Eller LA, Serwadda D, Sewankambo NK, Reynolds SJ, Quinn TC, Gray RH, Wawer MJ, Whalen CC.

J Acquir Immune Defic Syndr, 2010: 54(2): 180-4, 10.1097/QAI.0b013e3181c98fc0

27 Nov 2009

HIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda.

Kiwanuka N, Laeyendecker O, Quinn TC, Wawer MJ, Shepherd J, Robb M, Kigozi G, Kagaayi J, Serwadda D, Makumbi FE, Reynolds SJ, Gray RH.

AIDS, 2009: 23(18): 2479-84, 10.1097/QAD.0b013e328330cc08

1 Oct 2016

Geographic HIV type 1 subtype distribution in Rakai district, Uganda.

Collinson-Streng AN, Redd AD, Sewankambo NK, Serwadda D, Rezapour M, Lamers SL, Gray RH, Wawer MJ, Quinn TC, Laeyendecker O.

AIDS Res Hum Retroviruses, 2009: 25(10): 1045-8, 10.1089/aid.2009.0127

10 Sep 2009

Spatial phylodynamics of HIV-1 epidemic emergence in east Africa.

Gray RR, Tatem AJ, Lamers S, Hou W, Laeyendecker O, Serwadda D, Sewankambo N, Gray RH, Wawer M, Quinn TC, Goodenow MM, Salemi M.

AIDS, 2009: 23(14): F9-F17, 10.1097/QAD.0b013e32832faf61

1 Mar 2008

Effect of human immunodeficiency virus Type 1 (HIV-1) subtype on disease progression in persons from Rakai, Uganda, with incident HIV-1 infection.

Kiwanuka N, Laeyendecker O, Robb M, Kigozi G, Arroyo M, McCutchan F, Eller LA, Eller M, Makumbi F, Birx D, Wabwire-Mangen F, Serwadda D, Sewankambo NK, Quinn TC, Wawer M, Gray R.

J Infect Dis, 2008: 197(5): 707-13, 10.1086/527416

Molecular epidemiology of HIV-1 subtypes in southern China.

Laeyendecker O, Zhang GW, Quinn TC, Garten R, Ray SC, Lai S, Liu W, Chen J, Yu XF.

J Acquir Immune Defic Syndr, 2008: 38(3): 356-62,

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