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HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

1 year 6 months ago

RT @JustinLessler: Preprint with our look at the literature on #HIV incidencenin sub-Saharan Africa with @KateGrabowski and… https://t.co/6Hj4ac7HU3
4 years 7 months ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
5 years 2 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
5 years 6 months ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
5 years 7 months ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
5 years 11 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
5 years 11 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda.

Redd AD, Mullis CE, Serwadda D, Kong X, Martens C, Ricklefs SM, Tobian AA, Xiao C, Grabowski MK, Nalugoda F, Kigozi G, Laeyendecker O, Kagaayi J, Sewankambo N, Gray RH, Porcella SF, Wawer MJ, Quinn TC.

J Infect Dis, 2012: 206: 267-74, 10.1093/infdis/jis325

1 Oct 2011

Transmission selects for HIV-1 strains of intermediate virulence: a modelling approach.

Shirreff G, Pellis L, Laeyendecker O, Fraser C.

PLoS Comput Biol, 2011: 7(10): e1002185, 10.1371/journal.pcbi.1002185

27 Jan 2011

Increased rate of CD4+ T-cell decline and faster time to antiretroviral therapy in HIV-1 subtype CRF01_AE infected seroconverters in Singapore.

Ng OT, Lin L, Laeyendecker O, Quinn TC, Sun YJ, Lee CC, Leo YS.

PLoS One, 2011: 6(1): e15738, 10.1371/journal.pone.0015738

1 Oct 2011

Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms.

Ng OT, Munshaw S, Lamers SL, Chew KK, Lin L, Redd AD, Manucci J, Quinn TC, Ray SC, Chua A, Leo YS, Laeyendecker O.

AIDS Res Hum Retroviruses, 2011: (10): 1135-7, 10.1089/AID.2010.0364

Immunologic basis for revaccination of HIV-infected children receiving HAART.

Rainwater-Lovett K, Moss WJ.

Future Virol, 2011: 6: 59-71., 10.2217/fvl.10.75

1 Oct 2010

Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002.

Conroy SA, Laeyendecker O, Redd AD, Collinson-Streng A, Kong X, Makumbi F, Lutalo T, Sewankambo N, Kiwanuka N, Gray RH, Wawer MJ, Serwadda D, Quinn TC; Rakai Health Sciences Program.

AIDS Res Hum Retroviruses, 2010: (10): 1087-91, 10.1089/aid.2010.0054

6 May 2010

HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.

Hollingsworth TD, Laeyendecker O, Shirreff G, Donnelly CA, Serwadda D, Wawer MJ, Kiwanuka N, Nalugoda F, Collinson-Streng A, Ssempijja V, Hanage WP, Quinn TC, Gray RH, Fraser C

PLoS Pathog, 2010: 6(5): e1000876, 10.1371/journal.ppat.1000876

1 Jun 2010

HIV-1 viral subtype differences in the rate of CD4+ T-cell decline among HIV seroincident antiretroviral naive persons in Rakai district, Uganda.

Kiwanuka N, Robb M, Laeyendecker O, Kigozi G, Wabwire-Mangen F, Makumbi FE, Nalugoda F, Kagaayi J, Eller M, Eller LA, Serwadda D, Sewankambo NK, Reynolds SJ, Quinn TC, Gray RH, Wawer MJ, Whalen CC.

J Acquir Immune Defic Syndr, 2010: 54(2): 180-4, 10.1097/QAI.0b013e3181c98fc0

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