HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

1 year 2 weeks ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
1 year 7 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
2 years 2 weeks ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
2 years 2 weeks ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
2 years 5 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
2 years 5 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

Penile Immune Activation and Risk of HIV Shedding: A Prospective Cohort Study.

Patel EU, Kirkpatrick AR, Grabowski MK, Kigozi G, Gray RH, Prodger JL, Redd AD, Nalugoda F, Serwadda D, Wawer MJ, Quinn TC, Tobian AAR.

Clin Infect Dis, 2016: 10.1093/cid/ciw847

Moving towards a reliable HIV incidence test - current status, resources available, future directions and challenges ahead.

Murphy G, Pilcher CD, Keating SM, Kassanjee R, Facente SN, Welte A, Grebe E, Marson K, Busch MP, Dailey P, Parkin N, Osborn J, Ongarello S, Marsh K, Garcia-Calleja JM; Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA).

Epidemiol Infect, 2016: 1-17, 10.1017/S0950268816002910

Effect of the US National HIV/AIDS Strategy targets for improved HIV care engagement: a modelling study.

Shah M, Perry A, Risher K, Kapoor S, Grey J, Sharma A, Rosenberg ES, Del Rio C, Sullivan P, Dowdy DW.

Lancet HIV, 2016: 3: e140-6, 10.1016/S2352-3018(16)00007-2

The Epidemiologic and Economic Impact of Improving HIV Testing, Linkage, and Retention in Care in the United States.

Shah M, Risher K, Berry SA, Dowdy DW.

Clin Infect Dis, 2016: 62: 220-9, 10.1093/cid/civ801

A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda.

Blanquart F, Grabowski MK, Herbeck J, Nalugoda F, Serwadda D, Eller MA, Robb ML, Gray R, Kigozi G, Laeyendecker O, Lythgoe KA, Nakigozi G, Quinn TC, Reynolds SJ, Wawer MJ, Fraser C.

Elife, 2016: 5: e20492, 10.7554/eLife.20492

8 Nov 2016

Identifying transmission clusters with Cluster Picker and HIV-TRACE.

Rose R, Lamers SL, Dollar JJ, Grabowski MK, Hodcroft EB, Ragonnet-Cronin M, Wertheim JO, Redd AD, German D, Laeyendecker O.

AIDS Res Hum Retroviruses., 2016: 10.1089/AID.2016.0205

1 Dec 2016

The effect of a conditional cash transfer on HIV incidence in young women in rural South Africa (HPTN 068): a phase 3, randomised controlled trial.

Pettifor A, MacPhail C, Hughes JP, Selin A, Wang J, Gómez-Olivé FX, Eshleman SH, Wagner RG, Mabuza W, Khoza N, Suchindran C, Mokoena I, Twine R, Andrew P, Townley E, Laeyendecker O, Agyei Y, Tollman S, Kahn K.

Lancet Glob Health, 2016: Dec;4(12): e978-e988, 10.1016/S2214-109X(16)30253-4

1 Feb 2016

Evaluation of hidden HIV infections in an urban ED with a rapid HIV screening program.

Hsieh YH, Kelen GD, Beck KJ, Kraus CK, Shahan JB, Laeyendecker OB, Quinn TC, Rothman RE.

Am J Emerg Med, 2016: 34(2): 180-4, 10.1016/j.ajem.2015.10.002

Infectious Disease Dynamics

HIV Dynamics

HIV Dynamics

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HIV Dynamics

HIV Dynamics

Updates #HIV

Publications

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