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HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

4 months 6 days ago

RT @JustinLessler: Preprint with our look at the literature on #HIV incidencenin sub-Saharan Africa with @KateGrabowski and… https://t.co/6Hj4ac7HU3
3 years 4 months ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
3 years 11 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
4 years 4 months ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
4 years 4 months ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
4 years 9 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
4 years 9 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

9 Jan 2020

Recombination analysis of near full-length HIV-1 sequences and the identification of a potential new Circulating Recombinant Form from Rakai, Uganda

Capoferri AA, Lamers S, Grabowski M, Rose RR, Wawer M, Serwadda D, Gray R, Quinn TC, Kigozi G, Kagaayi J, Laeyendecker O

AIDS Res Hum Retroviruses, 2020: 10.1089/AID.2019.0150

20 Feb 2020

Migration, hotspots, and dispersal of HIV infection in Rakai, Uganda

Graboswki MK, Lessler J, Bazaale J, Nabukala D, Nakinga J, Nantume B, Ssekasanvu J, Raynolds SJ, Ssekubugu R, Nalugoda F, Kigozi G, Kagaayi J, Santelli J, Kennedy C, Wawer MJ, Serwadda D, Chang LW, Gray RH, the Rakai Health Sciences Program

Nat Commun, 2020: 11(1): 976, 10.1038/s41467-020-14636-y

29 Mar 2019

Inferring HIV-1 transmission networks and sources of epidemic spread in Africa with deep-sequence phylogenetic analysis

Ratmann O, Grabowski MK, Hall M, Golubchik T, Wymant C, Abeler-Dörner L, Bonsall D, Hoppe A, Brown AL, de Oliveira T, Gall A, Kellam P, Pillay D, Kagaayi J, Kigozi G, Quinn TC, Wawer MJ, Laeyendecker O, Serwadda D, Gray RH, Fraser C; PANGEA Consortium and Rakai Health Sciences Program.

Nat Commun, 2019: 10(1): 1411, 10.1038/s41467-019-09139-4

12 Feb 2019

Cross-sectional HIV Incidence Estimation Accounting for Heterogeneity Across Communities

Xu Y, Laeyendecker O, Wang R

Biometrics, 2019: 10.1111/biom.13046

24 Apr 2019

Operational characteristics of antiretroviral therapy clinics in Zambia: a time and motion analysis

Tampi RP, Tembo T, Mukumba-Mwenechanya M, Sharma A, Dowdy DW, Holmes CB, Bolton-Moore C, Sikazwe I, Tucker A, Sohn H

BMC Health Serv Res, 2019: 19(1): 244, 10.1186/s12913-019-4096-z

4 Oct 2019

Longitudinal antibody responses in people who inject drugs infected with similar HIV strains

Redd AD, Doria-Rose NA, Weiner JA, Nason M, Seivers M, Schmidt SD, Laeyendecker O, Martens C, Bruno D, Keele BF, Raju N, Georgiev IS, Lamers SL, Astemborski J, Kirk GD, Mascola JR, Ackerman ME, Mehta SH, Quinn TC

J Infect Dis, 2019: 10.1093/infdis/jiz503

30 Aug 2019

Cross-sectional HIV incidence estimation in an evolving epidemic

Morrison D, Laeyendecker O, Brookmeyer R

Stat Med, 2019: 38(19): 3614-3627, 10.1002/sim.8196

30 Apr 2019

Comprehensive Profiling of HIV Antibody Evolution

Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HB

Cell Rep, 2019: 27(5): 1422-1433, 10.1016/j.celrep.2019.03.097

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