HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

1 year 4 months ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
1 year 11 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
2 years 4 months ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
2 years 4 months ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
2 years 9 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
2 years 9 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

1 Dec 2018

Cross-Sectional HIV Incidence Estimation with Missing Biomarkers

Morrison D, Laeyendecker O, Konikoff J, Brookmeyer R

Stat Commun Infect Dis, 2018: 10(1): pii: 20170, 10.1515/scid-2017-0003

HIV viral suppression and geospatial patterns of HIV antiretroviral therapy treatment facility use in Rakai, Uganda.

Billioux VG, Grabowski MK, Ssekasanvu J, Reynolds SJ, Berman A, Bazaale J, Patel EU, Bugos E, Ndyanabo A, Kisakye A, Kagaayi J, Gray RH, Nakigozi G, Ssekubugu R, Nalugoda F, Serwadda D, Wawer MJ, Chang LW.

AIDS, 2018: 10.1097/QAD.0000000000001761

Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation.

Patel EU, Gianella S, Newell K, Tobian AAR Kirkpatrick AR, Nalugoda F, Grabowski MK, Gray RH, Serwadda D, Quinn T, Redd AD, Reynolds SJ.

AIDS, 2017: 10.1097/QAD.0000000000001412

26 Jan 2017

Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller.

Walker-Sperling VE, Pohlmeyer CW, Veenhuis RT, May M, Luna KA, Kirkpatrick AR, Laeyendecker O, Cox AL, Carrington M, Bailey JR, Arduino RC, Blankson JN.

EBioMedicine, 2017: pii: S2352-3964(17): 30038-5, 10.1016/j.ebiom.2017.01.034

Analysis of HIV Diversity in HIV-Infected Black Men Who Have Sex with Men (HPTN 061).

Chen I, Chau G, Wang J, Clarke W, Marzinke MA, Cummings V, Breaud A, Laeyendecker O, Fields SD, Griffith S, Scott HM, Shoptaw S, Del Rio C, Magnus M, Mannheimer S, Tieu HV, Wheeler DP, Mayer KH, Koblin BA, Eshleman SH.

PLoS One, 2017: 11(12): e0167629, 10.1371/journal.pone.0167629

HIV-1 full-genome phylogenetics of generalized epidemics in sub-Saharan Africa: impact of missing nucleotide characters in next-generation sequences.

Ratmann O, Wymant C, Colijn C, Danaviah S, Essex M, Frost SDW, Gall A, Gaiseitsiwe S, Grabowski M, Gray R, Guindon S, von Haeseler A, Kaleebu P, Kendall M, Kozlov A, Manasa J, Minh BQ, Moyo S, Novitsky V, Nsubuga R, Pillay S, Quinn TC, Serwadda D, Ssemwanga D, Stamatakis A, Trifinopoulos J, Wawer M, Leigh Brown A, de Oliveira T, Kellam P, Pillay D, Fraser C.

AIDS Res Hum Retroviruses, 2017: 10.1089/AID.2017.0061

A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda.

Blanquart F, Grabowski MK, Herbeck J, Nalugoda F, Serwadda D, Eller MA, Robb ML, Gray R, Kigozi G, Laeyendecker O, Lythgoe KA, Nakigozi G, Quinn TC, Reynolds SJ, Wawer MJ, Fraser C.

Elife, 2016: 5: e20492, 10.7554/eLife.20492

8 Nov 2016

Identifying transmission clusters with Cluster Picker and HIV-TRACE.

Rose R, Lamers SL, Dollar JJ, Grabowski MK, Hodcroft EB, Ragonnet-Cronin M, Wertheim JO, Redd AD, German D, Laeyendecker O.

AIDS Res Hum Retroviruses., 2016: 10.1089/AID.2016.0205

Infectious Disease Dynamics

HIV Dynamics

HIV Dynamics

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HIV Dynamics

HIV Dynamics

Updates #HIV

Publications

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