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HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

1 month 1 week ago

RT @JustinLessler: Preprint with our look at the literature on #HIV incidencenin sub-Saharan Africa with @KateGrabowski and… https://t.co/6Hj4ac7HU3
3 years 1 month ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
3 years 9 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
4 years 1 month ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
4 years 1 month ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
4 years 6 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
4 years 6 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

27 May 2020

Impact of Early Antiretroviral Treatment Initiation on Performance of Cross-Sectional Incidence Assays

Klock E, Mwinnya G, Eller LA, Fernandez RE, Kibuuka H, Nitayaphan S, Kosgei J, Moore RD, Robb M, Eshleman SH, Laeyendecker O

AIDS Res Hum Retroviruses, 2020: 36(7): 583-589, 10.1089/AID.2019.0286

18 Feb 2020

Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains

Redd AD, Doria-Rose NA, Weiner JA, Nason M, Seivers M, Schmidt SD, Laeyendecker O, Martens C, Bruno D, Keele BF, Raju N, Georgiev IS, Lamers SL, Astemborski J, Kirk GD, Mascola JR, Ackerman ME, Mehta SH, Quinn TC

J Infect Dis, 2020: 221(5): 756-765, 10.1093/infdis/jiz503

30 Aug 2019

Cross-sectional HIV incidence estimation in an evolving epidemic

Morrison D, Laeyendecker O, Brookmeyer R

Stat Med, 2019: 38(19): 3614-3627, 10.1002/sim.8196

30 Apr 2019

Comprehensive Profiling of HIV Antibody Evolution

Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HB

Cell Rep, 2019: 27(5): 1422-1433, 10.1016/j.celrep.2019.03.097

7 Nov 2019

Advancing HIV Vaccine Research With Low-Cost High-Performance Computing Infrastructure: An Alternative Approach for Resource-Limited Settings

Mabvakure BM, Rott R, Dobrowsky L, Van Heusden P, Morris L, Scheepers C, Moore PL

Bioinform Biol Insights, 2019: 13: 10.1177/1177932219882347

1 Feb 2019

A Window Into the HIV Epidemic from a South African Emergency Department

Hansoti B, Stead D, Eisenberg A, Mvandaba N, Mwinnyaa G, Patel EU, Parrish A, Reynolds SJ, Redd AD, Fernandez R, Rothman RE, Laeyendecker O, Quinn TC

AIDS Res Hum Retroviruses, 2019: 35(2): 139-144, 10.1089/AID.2018.0127

19 Aug 2019

Targeting the HIV Epidemic in South Africa: The Need for Testing and Linkage to Care in Emergency Departments

Hansoti B, Mwinnyaa G, Hahn E, Rao A, Black J, Chen V, Clark K, Clarke W, Eisenberg AL, Fernandez R, Iruedo J, Laeyendecker O, Maharaj R, Mda P, Miller J, Mvandaba N, Nyanisa Y, Reynolds SJ, Redd AD, Ryan S, Stead DF, Wallis LA, Quinn TC

EClinicalMedicine, 2019: 15: 14-22, 10.1016/j.eclinm.2019.08.007

1 Jan 2020

HIV drug resistance in a cohort of HIV-infected MSM in the United States

Fogel JM, Sivay MV, Cummings V, Wilson EA, Hart S, Gamble T, Laeyendecker O, Fernandez RE, Del Rio C, Batey DS, Mayer KH, Farley JE, McKinstry L, Hughes JP, Remien RH, Beyrer C, Eshleman SH

AIDS, 2019: 34(1): 91-101, 10.1097/QAD.0000000000002394

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