HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

5 months 3 weeks ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
10 months 3 weeks ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
10 months 3 weeks ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
1 year 3 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
1 year 3 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation.

Patel EU, Gianella S, Newell K, Tobian AAR Kirkpatrick AR, Nalugoda F, Grabowski MK, Gray RH, Serwadda D, Quinn T, Redd AD, Reynolds SJ.

AIDS, 2017: 10.1097/QAD.0000000000001412

26 Jan 2017

Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller.

Walker-Sperling VE, Pohlmeyer CW, Veenhuis RT, May M, Luna KA, Kirkpatrick AR, Laeyendecker O, Cox AL, Carrington M, Bailey JR, Arduino RC, Blankson JN.

EBioMedicine, 2017: pii: S2352-3964(17): 30038-5, 10.1016/j.ebiom.2017.01.034

Analysis of HIV Diversity in HIV-Infected Black Men Who Have Sex with Men (HPTN 061).

Chen I, Chau G, Wang J, Clarke W, Marzinke MA, Cummings V, Breaud A, Laeyendecker O, Fields SD, Griffith S, Scott HM, Shoptaw S, Del Rio C, Magnus M, Mannheimer S, Tieu HV, Wheeler DP, Mayer KH, Koblin BA, Eshleman SH.

PLoS One, 2017: 11(12): e0167629, 10.1371/journal.pone.0167629

HIV-1 full-genome phylogenetics of generalized epidemics in sub-Saharan Africa: impact of missing nucleotide characters in next-generation sequences.

Ratmann O, Wymant C, Colijn C, Danaviah S, Essex M, Frost SDW, Gall A, Gaiseitsiwe S, Grabowski M, Gray R, Guindon S, von Haeseler A, Kaleebu P, Kendall M, Kozlov A, Manasa J, Minh BQ, Moyo S, Novitsky V, Nsubuga R, Pillay S, Quinn TC, Serwadda D, Ssemwanga D, Stamatakis A, Trifinopoulos J, Wawer M, Leigh Brown A, de Oliveira T, Kellam P, Pillay D, Fraser C.

AIDS Res Hum Retroviruses, 2017: 10.1089/AID.2017.0061

A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda.

Blanquart F, Grabowski MK, Herbeck J, Nalugoda F, Serwadda D, Eller MA, Robb ML, Gray R, Kigozi G, Laeyendecker O, Lythgoe KA, Nakigozi G, Quinn TC, Reynolds SJ, Wawer MJ, Fraser C.

Elife, 2016: 5: e20492, 10.7554/eLife.20492

8 Nov 2016

Identifying transmission clusters with Cluster Picker and HIV-TRACE.

Rose R, Lamers SL, Dollar JJ, Grabowski MK, Hodcroft EB, Ragonnet-Cronin M, Wertheim JO, Redd AD, German D, Laeyendecker O.

AIDS Res Hum Retroviruses., 2016: 10.1089/AID.2016.0205

1 Dec 2016

The effect of a conditional cash transfer on HIV incidence in young women in rural South Africa (HPTN 068): a phase 3, randomised controlled trial.

Pettifor A, MacPhail C, Hughes JP, Selin A, Wang J, Gómez-Olivé FX, Eshleman SH, Wagner RG, Mabuza W, Khoza N, Suchindran C, Mokoena I, Twine R, Andrew P, Townley E, Laeyendecker O, Agyei Y, Tollman S, Kahn K.

Lancet Glob Health, 2016: Dec;4(12): e978-e988, 10.1016/S2214-109X(16)30253-4

1 Feb 2016

Evaluation of hidden HIV infections in an urban ED with a rapid HIV screening program.

Hsieh YH, Kelen GD, Beck KJ, Kraus CK, Shahan JB, Laeyendecker OB, Quinn TC, Rothman RE.

Am J Emerg Med, 2016: 34(2): 180-4, 10.1016/j.ajem.2015.10.002

Infectious Disease Dynamics

HIV Dynamics

HIV Dynamics

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HIV Dynamics

HIV Dynamics

Updates #HIV

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