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HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

1 month 1 week ago

RT @JustinLessler: Preprint with our look at the literature on #HIV incidencenin sub-Saharan Africa with @KateGrabowski and… https://t.co/6Hj4ac7HU3
3 years 1 month ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
3 years 9 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
4 years 1 month ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
4 years 1 month ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
4 years 6 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
4 years 6 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

20 Feb 2020

Migration, hotspots, and dispersal of HIV infection in Rakai, Uganda

Graboswki MK, Lessler J, Bazaale J, Nabukala D, Nakinga J, Nantume B, Ssekasanvu J, Raynolds SJ, Ssekubugu R, Nalugoda F, Kigozi G, Kagaayi J, Santelli J, Kennedy C, Wawer MJ, Serwadda D, Chang LW, Gray RH, the Rakai Health Sciences Program

Nat Commun, 2020: 11(1): 976, 10.1038/s41467-020-14636-y

26 Aug 2020

HIV serologically indeterminate individuals: Future HIV status and risk factors

Mwinnyaa G, Grabowski MK, Gray RH, Wawer M, Chang LW, Ssekasanvu J, Kagaayi J, Kigozi G, Kalibbala S, Galiwango RM, Ndyanabo A, Serwadda D, Quinn TC, Reynolds SJ, Laeyendecker O

PLoS One, 2020: 15(8): e0237633, 10.1371/journal.pone.0237633

7 Aug 2020

Persistence of HIV transmission clusters among people who inject drugs

Rose R, Cross S, Lamers SL, Astemborski J, Kirk GD, Mehta SH, Sievers M, Martens C, Bruno D, Redd AD, Laeyendecker O.

AIDS, 2020: 10.1097/QAD.0000000000002662

28 May 2020

HIV-1 Subtype Distribution and Diversity Over 18 Years in Rakai, Uganda

Lamers SL, Rose R, Cross S, Rodriguez CW, Redd AD, Quinn TC, Serwadda D, Kagaayi J, Kigozi G, Galiwango R, Gray RH, Grabowski MK, Laeyendecker O

AIDS Res Hum Retroviruses, 2020: 36(6): 522-526, 10.1089/aid.2020.0062

27 May 2020

Impact of Early Antiretroviral Treatment Initiation on Performance of Cross-Sectional Incidence Assays

Klock E, Mwinnya G, Eller LA, Fernandez RE, Kibuuka H, Nitayaphan S, Kosgei J, Moore RD, Robb M, Eshleman SH, Laeyendecker O

AIDS Res Hum Retroviruses, 2020: 36(7): 583-589, 10.1089/AID.2019.0286

18 Feb 2020

Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains

Redd AD, Doria-Rose NA, Weiner JA, Nason M, Seivers M, Schmidt SD, Laeyendecker O, Martens C, Bruno D, Keele BF, Raju N, Georgiev IS, Lamers SL, Astemborski J, Kirk GD, Mascola JR, Ackerman ME, Mehta SH, Quinn TC

J Infect Dis, 2020: 221(5): 756-765, 10.1093/infdis/jiz503

18 Feb 2020

Determination of HIV status and identification of incident HIV infections in a large, community-randomized trial: HPTN 071 (PopART)

Eshleman SH, Piwowar-Manning E, Wilson EA, Lennon D, Fogel JM, Agyei Y, Sullivan PA, Weng L, Moore A, Laeyendecker O, Kosloff B, Bwalya J, Maarman G, van Deventer A, Floyd S, Bock P, Ayles H, Fidler S, Hayes R, Donnell D; HPTN 071 (PopART) Study Team

J Int AIDS Soc, 2020: 23(2): e25452, 10.1002/jia2.25452

14 Jan 2020

Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda.

Ratmann O, Kagaayi J, Hall M, Golubchick T, Kigozi G, Xi X, Wymant C, Nakigozi G, Abeler-Dörner L, Bonsall D, Gall A, Hoppe A, Kellam P, Bazaale J, Kalibbala S, Laeyendecker O, Lessler J, Nalugoda F, Chang LW, de Oliveira T, Pillay D, Quinn TC, Reynolds SJ, Spencer SEF, Ssekubugu R, Serwadda D, Wawer MJ, Gray RH, Fraser C, Grabowski MK; Rakai Health Sciences Program and the Pangea HIV Consortium.

Lancet HIV, 2020: 10.1016/S2352-3018(19)30378-9

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