HIV Dynamics

We work closely with the Rakai Health Sciences Program and other collaborators to study HIV transmission in sub-Saharan Africa

We work on a variety of epidemiological studies focused on HIV transmission dynamics and the impact of prevention interventions. Our research largely takes place in Sub-Saharan Africa but we have also collaborated on domestic initatives.

We closely collaborate with the Rakai Health Sciences Program (RHSP) in Uganda, which is one of the leading HIV research institutions in Sub-Saharan Africa. Rakai, located in Southwest Uganda, is where the first AIDS cases were identified in Eastern Africa and today it remains one of the highest-burden districts in the region with an overall HIV prevalence of ~14%. However, within Rakai there is substantial geographic heterogeneity in HIV prevalence ranging from 9-43% at the community-level. We currently support NIH and BMGF initiatives to understand the role of extremely-high-prevalence communities (i.e. "geographic hotspots") and other key populations within the broader regional epidemic with the overarching goal of informing targeting HIV prevention initiatives under PEPFAR Phase III. Our work with RHSP includes dynamic HIV modelling and viral phylogenetics conducted in collaboration with the PANGEA-HIV consortium and researchers (and friends!) at Oxford University and Imperial College London in the UK.

We also have an iniative supported by the Johns Hopkins Center for AIDS Research/NIH to use network models and viral phylogenetics to inform real-time interventions to prevent HIV among young men who have sex with men in Baltimore City, Maryland.

Updates #HIV

2 years 9 months ago

Congratulations to @KateGrabowski and the Rakai team on there important paper on #HIV incidence declines in Rakai in @NEJM
3 years 4 months ago

Congratulations to @katierisher on her exceptional defense of her dissertation today. #HIV
3 years 9 months ago

What can phylogenetics tell us about #HIV transmission? @KateGrabowski and @JustinLessler comment in @TheLancetHIV. https://t.co/b2Pc28yFHG
3 years 9 months ago

RT @KateGrabowski: Congrats to Jess Prodger & Rakai team on new paper looking at inflammation and HIV risk in men! @JHIDDynamics #HIV https://t.co/PFeVseXVtK
4 years 2 months ago

Congrats to @KateGrabowski and the whole RHSP team on the their paper in Lancet HIV. With a commentary no less! https://t.co/cDgxIDYvA7 #HIV
4 years 2 months ago

Congrats to @KateGrabowski, Allison A., Errol F., others on @HopkinsCFAR award to study HIV transmission in Baltimore w/phylogenetics! #HIV

Publications

20 Feb 2020

Migration, hotspots, and dispersal of HIV infection in Rakai, Uganda

Graboswki MK, Lessler J, Bazaale J, Nabukala D, Nakinga J, Nantume B, Ssekasanvu J, Raynolds SJ, Ssekubugu R, Nalugoda F, Kigozi G, Kagaayi J, Santelli J, Kennedy C, Wawer MJ, Serwadda D, Chang LW, Gray RH, the Rakai Health Sciences Program

Nat Commun, 2020: 11(1): 976, 10.1038/s41467-020-14636-y

14 Jan 2020

Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda.

Ratmann O, Kagaayi J, Hall M, Golubchick T, Kigozi G, Xi X, Wymant C, Nakigozi G, Abeler-Dörner L, Bonsall D, Gall A, Hoppe A, Kellam P, Bazaale J, Kalibbala S, Laeyendecker O, Lessler J, Nalugoda F, Chang LW, de Oliveira T, Pillay D, Quinn TC, Reynolds SJ, Spencer SEF, Ssekubugu R, Serwadda D, Wawer MJ, Gray RH, Fraser C, Grabowski MK; Rakai Health Sciences Program and the Pangea HIV Consortium.

Lancet HIV, 2020: 10.1016/S2352-3018(19)30378-9

10 Jan 2020

Evaluation of phylogenetic methods for inferring the direction of HIV transmission: HPTN 052

Zhang Y, Wymant C, Laeyendecker O, Grabowski MK, Hall M, Hudelson S, Piwowar-Manning E, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Mills LA, Santos BR, Grinsztejn B, Pilotto JH, Chariyalertsak S, Makhema J, Chen YQ, Cohen MS, Fraser C, Eshleman SH.

Clin Infect Dis, 2020: 10.1093/cid/ciz1247

9 Jan 2020

Recombination analysis of near full-length HIV-1 sequences and the identification of a potential new Circulating Recombinant Form from Rakai, Uganda

Capoferri AA, Lamers S, Grabowski M, Rose RR, Wawer M, Serwadda D, Gray R, Quinn TC, Kigozi G, Kagaayi J, Laeyendecker O

AIDS Res Hum Retroviruses, 2020: 10.1089/AID.2019.0150

2 Apr 2019

Integrated HIV testing, prevention, and treatment intervention for key populations in India: a cluster-randomised trial

Solomon SS, Solomon S, McFall AM, Srikrishnan AK, Anand S, Verma V, Vasudevan CK, Balakrishnan P, Ogburn EL, Moulton LH, Kumar MS, Sachdeva KS, Laeyendecker O, Celentano DD, Lucas GM, Mehta SH; Indian National Collaboration on AIDS Study.

Lancet HIV, 2019: 10.1016/S2352-3018(19)30034-7

29 Oct 2019

Depression and incident HIV in adolescent girls and young women in HPTN 068: Targets for prevention and mediating factors

Goin DE, Pearson RM, Craske MG, Stein A, Pettifor A,, Lippman SA, Kahn K, Neilands TB, Hamilton EL, Selin A, MacPhail C,, Wagner RG, Gomez-Olive FX, Twine R, Hughes JP, Agyei Y, Laeyendecker O, Tollman S, Ahern J

Am J Epidemiol, 2019: 10.1093/aje/kwz238

29 Mar 2019

The benefit of immediate compared to deferred ART on CD4+ Cell count recovery in early HIV infection

Sharma S, Schlusser KE, Torre P, Tambussi G, Draenert R, Pinto AN, Metcalf JA, Neaton JD, Laeyendecker O; INSIGHT START Study Group.

AIDS, 2019: 10.1097/QAD.0000000000002219

29 Mar 2019

Inferring HIV-1 transmission networks and sources of epidemic spread in Africa with deep-sequence phylogenetic analysis

Ratmann O, Grabowski MK, Hall M, Golubchik T, Wymant C, Abeler-Dörner L, Bonsall D, Hoppe A, Brown AL, de Oliveira T, Gall A, Kellam P, Pillay D, Kagaayi J, Kigozi G, Quinn TC, Wawer MJ, Laeyendecker O, Serwadda D, Gray RH, Fraser C; PANGEA Consortium and Rakai Health Sciences Program.

Nat Commun, 2019: 10(1): 1411, 10.1038/s41467-019-09139-4

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HIV Dynamics

HIV Dynamics

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HIV Dynamics

HIV Dynamics

Updates #HIV

Publications

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Images