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Fluscape

Immune Landscapes of Human Influenza in Households, Towns, and Cities in Southern China

The goal of Fluscape is to characterize the immunological profiles to human influenza in space and time of individuals residing in the Guangzhou Province, China, and to capture the transmission dynamics contributing to those observed immunological distributions through computational models.

Principal Investigator

Justin Lessler Associate Professor

Derek Cummings Professor

Steven Riley Professor

Funders

NIH Ecology of Infectious Disease Program

National Institute on Aging

Wellcome Trust

Collaborators

Guangzhou Hospital No. 12

Hong Kong University

University of Liverpool

Imperial College London

University of Florida Emerging Pathogens Institute

Publications

A comparison of hemagglutination inhibition and neutralization assays for characterizing immunity to seasonal influenza A.

Truelove S, Zhu H, Lessler J, Riley S, Read JM, Wang S, Kwok KO, Guan Y, Jiang CQ, Cummings DAT.

Influenza Other Respir Viruses, 2016: 10(6): 518-524, 10.1111/irv.12408

Cohort Profile: A study of influenza immunity in the urban and rural Guangzhou region of China: the Fluscape Study.

Jiang CQ, Lessler J, Kim L, Kwok KO, Read JM, Wang S, Tan L, Hast M, Zhu H, Guan Y, Riley S, Cummings DA.

Int J Epidemiol, 2016: 10.1093/ije/dyv353

Estimating the life course of influenza AH3N2 antibody responses from cross-sectional data.

Kucharski AJ, Lessler J, Read JM, Zhu H, Jiang CQ, Guan Y, Cummings DA, Riley S.

PLoS Biol, 2015: 13: e1002082, 10.1371/journal.pbio.1002082

Social contacts and the locations in which they occur as risk factors for influenza infection.

Kwok KO, Cowling BJ, Wei VW, Wu KM, Read JM, Lessler J, Cummings DA, Peiris JS, Riley S.

Proc Biol Sci, 2014: 281: 20140709, 10.1098/rspb.2014.0709

Social mixing patterns in rural and urban areas of southern China.

Read JM, Lessler J, Riley S, Wang S, Tan LJ, Kwok KO, Guan Y, Jiang CQ, Cummings DA.

Proc Biol Sci, 2014: 281: 20140268, 10.1098/rspb.2014.0268

Evidence for antigenic seniority in influenza A H3N2 antibody responses in southern China.

Lessler J, Riley S, Read JM, Wang S, Zhu H, Smith GJ, Guan Y, Jiang CQ, Cummings DA.

PLoS Pathog, 2012: 8: e1002802, 10.1371/journal.ppat.1002802

Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China.

Lessler J, Cummings DA, Read JM, Wang S, Zhu H, Smith GJ, Guan Y, Jiang CQ, Riley S.

Nat Commun, 2011: 2: 423, 10.1038/ncomms1432